Endocrine Abstracts

Introduction: Vitamin D, primarily known for its role in calcium–phosphorus homeostasis, is also a significant immunomodulatory factor. Vitamin D deficiency has been reported in some autoimmune disorders. Recently, vitamin D level in autoimmune thyroiditis (Hashimoto’s thyroiditis (HT)) has become the subject of researchers’ interest.Objectives: This study aims to assess vitamin 25-OH-D3 levels in HT patients in comparison to a control gro...

Objectives: Aberrances in expression and sequence of miR-146a have a well-established role in pathogenesis of papillary thyroid carcinoma (PTC). The G/C heterozygosity in rs2910164 of miR-146a underlies genetic predisposition to PTC and occurs as a somatic mutation in thyroid tumors. Deleterious function of rs2910164 consists in creation of a new variant of microRNA, resulting from the fact that a single microRNA precursor gives rise to −5p and −3p microRNAs. The S...

Background: Chemerin (CHEM) is a newly-discovered adipokine involved in the immune, metabolic and reproductive processes. Low-grade state inflammation (LGSI) is a key element in the pathogenesis of metabolic syndrome (MS).Objectives: The aim of the study was to assess the effect of age on MS prevalence, androgenic status as well as on selected inflammatory indices and CHEM plasma concentrations. Additionally we investigated correlations between CHEM and ...

Objectives: Papillary thyroid carcinoma (PTC) exhibits aberrant expression of retinoic acid receptor β (RARβ), a retinoic acid-inducible transcription factor, essential for cellular growth and development. The mechanisms leading to decreased RARβ expression in tumors are unknown. We hypothesized that changes in expression of RARB, a gene encoding for RARβ, result from aberrant expression of microRNAs. We elucidated the miRNome of normal thyroid and...

Objectives: The sodium/iodide symporter (NIS) is a glycoprotein with unique ability of transporting iodine into the thyroid follicle. Apart from the importance in thyroid hormone synthesis, this function of NIS allows the use of radioactive iodine to target residual and metastatic thyroid cancer after thyroidectomy. However, 20–30% of thyroid tumors exhibit lowered expression of NIS, resulting in decreased uptake of radioiodine and inefficient post-surgical therapy. Mecha...

Objectives: Apical iodide transporter (AIT) is essential for thyroid homeostasis, functioning both as iodide transporter and a potent tumor suppressor. Its decreased levels observed in thyroid cancer underlie its progression and inefficiency of radioactive iodine treatment, used for ablation of post-operative and metastatic thyroid cancer cells. Mechanisms of AIT downregulation in cancer are largely unknown, but recent data on overexpression of microRNAs in thyroid cancer sugg...

Introduction: Papillary Thyroid Carcinoma (PTC) exhibits activation of MAPK (Mitogen-activated protein kinases) pathway, leading to uncontrolled cellular division and growth. Concomitantly, thyroid tumors exhibit aberrant expression of numerous microRNAs, which are non-coding RNAs that inhibit expression of protein-coding genes. Employing next-generation sequencing (NGS), we revealed comprehensive miRNA profiles of normal thyroid and PTC, and identified putative novel microRNA...

Type 1 deiodinase (D1) catalyses deiodination of tyroxine (T4), which leads either to synthesis of triiodothyronine or reverse triiodothyronine (rT3). Triiodothyronine (T3) regulates the expression of many tumour suppressor genes and oncogenes. We previously revealed that the expression of the whole pool of D1 transcripts was dramatically lowered in ccRCC tissues. One of the mechanism resulting in this aberration could be miRNA-mediated repress...

Aims: The aim of our study was to assess the relationships between systemic markers of general inflammation: interleukin 18 (IL-18) and C-reactive protein (CRP) and dehydroepiandrosterone (DHEA) as well as dehydroepiandrosterone sulphate (DHEA-S) serum levels, in addition to the anthropometrical and biochemical indices of metabolic syndrome (MS) in men over the age of 40.Patients and methods: In 271 randomly chosen men aged 40 to 80 years living in Lubus...

Type 1 deiodinase (D1) catalyses synthesis of triiodothyronine (T3) which regulates the expression of many tumor suppressor genes and oncogenes. We previously revealed that the expression of the whole pool of D1 transcripts was dramatically lowered in ccRCC tissues. One of the mechanims resulting in this aberration could be miRNA-mediated repression of target mRNAs. The aim of the study was 1) to analyze the expression of miRNA binding to 3′UTR of D1 in ccRCC; 2) ...